Treatment of multicentric or cranial mediastinal high-grade T-cell lymphoma in dogs with a first-line CCNU-L(-chlorambucil)-CHOP protocol

Eerstelijnsbehandeling met CCNU-L(-chloorambucil)-CHOP van honden met een hooggradig multicentrisch of mediastinaal T-cellymfoom

 

M. Ossowska1, E. Teske2, L. Beirens-van Kuijk1, M. Zandvliet2, J.P. de Vos1

 

1De Ottenhorst, Veterinary Oncology Referral Centre, van Diemenstraat 83, 4535 AR Terneuzen, the Netherlands

 

2Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, P.O. Box 80154, 3508 TD Utrecht, the Netherlands

 

ABSTRACT

 

This retrospective study determined disease free survival (DFS) and progression free survival (PFS) in chemo-naïve dogs with multicentric or cranial mediastinal high-grade T-cell lymphoma, treated with a first-line CCNU-L(-chlorambucil)-CHOP protocol. Of thirteen dogs with multicentric lymphoma, 92.3% achieved a complete remission (CR), and the median DFS and PFS was 317 and 256 days, respectively. Three dogs had cranial mediastinal lymphoma, and achieved a CR with a median DFS and PFS of 978 and 1007 days, respectively. The one- and two-year DFS/PFS probability estimate for dogs with multicentric lymphoma was 0.50/0.46 and 0.42/0.38, respectively, for dogs with cranial mediastinal lymphoma 0.67/0.67. Neutropenia and thrombocytopenia were reported in 52.9% and 50% of the dogs, respectively, while 56.3% experienced grade 1-4 nephrotoxicity, hypothesized to be lomustine-induced. It was concluded that, compared to historical data, the currently described first-line CCNU-L(-chlorambucil)CHOP protocol could benefit the survival of dogs with multicentric or cranial mediastinal high-grade T-cell lymphoma.

 

See more: http://vdt.ugent.be/sites/default/files/ArtEnglish03.pdf

 

 

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Andrea Strakova, Máire Ní Leathlobhair, Guo-Dong Wang, Ting-Ting Yin, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Jocelyn L Bisson, Artemio Castillo , omracheva, Karina F de Castro, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Stephen M Cutter, Laura Delgadillo Keenan, Edward M Donelan, Ibikunle A Faramade, Erika Flores Reynoso, Eleni Fotopoulou, Skye N Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Rodrigo F Häfelin Manrique, Joaquim JGP Henriques, Natalia Ignatenko, Debbie Koenig, Marta Lanza-Perea, Remo Lobetti, Adriana M Lopez Quintana, Thibault Losfelt, Gabriele Marino, Inigo Martincorena, Simón Martínez Castañeda, Mayra F Martínez-López, Michael Meyer, Berna Nakanwagi, Andrigo B De Nardi, Winifred Neunzig, Sally J Nixon, Marsden M Onsare, Antonio Ortega-Pacheco, Maria C Peleteiro, Ruth J Pye, John F Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K Schmeling, Olga Shamanova, Richard K Ssuna, Audrey E Steenland-Smit, Alla Svitich, Ismail Thoya Ngoka, Bogdan A Vițălaru, Anna P de Vos, Johan P de Vos, Oliver Walkinton, David C Wedge, Alvaro S Wehrle-Martinez, Mirjam G van der Wel, Sophie AE Widdowson, Elizabeth P Murchison.

 

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Inductively coupled plasma mass-spectrometric determination of platinum in excretion products of client-owned pet dogs.

Janssens T, Brouwers EE2, de Vos JP, de Vries N, Schellens JH4,5, Beijnen JH.

 
 

 

Determination of platinum surface contamination in veterinary and human oncology centres using inductively coupled plasma mass spectrometry.

Janssens T, Brouwers EE, de Vos JP, de Vries N, Schellens JH, Beijnen JH.

 

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Peri-articular Histiocytic Sarcoma and Previous Joint Disease in Bernese Mountain Dogs

L. van Kuijk, K. van Ginkel, J.P. de Vos, M.J. Brearley, J. Butinar, I. Gielen, E. van Garderen, K. Chiers, and P.S. Verhoeven.

 

Paper was presented at the annual meeting of the European Society of Veterinary Oncology, 19-20 March 2010, in Turin and at the Veterinary Cancer Society Congress, 30-31 October - 1 November 2010, in San Diego, CA.

 

Journal of Veterinary Internal Medicine. 2013; 27:293-299. DOI: 10.1111/jvim.12059

 

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Comparison between symptomatic treatment and lomustine supplementation in 71 dogs with intracranial, space-occupying lesions

S. Van Meervenne, P. S. Verhoeven, J. de Vos, I. M. V. L. Gielen, I. Polis, L. M. L. Van Ham

 

Journal of Veterinary and Comparative Oncology 2012. doi: 10.1111/j.1476-5829.2012.00336.x. [Epub ahead of print]

 

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Primary frontal sinus squamous cell carcinoma in three dogs treated with piroxicam combined with carboplatin or toceranib

J. de Vos, S. Ramos Vega, E. Noorman and P. de Vos

 

Journal of Veterinary and Comparative Oncology 2012; 10:206-213

 

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European consensus document on mast cell tumours in dogs and cats

L. Blackwood, S.Murphy, P. Buracco, J. P. De Vos, P. De Fornel-Thibaud, J. Hirschberger, M. Kessler, J. Pastor, F. Ponce, K. Savary-Bataille and D. J. Argyle.

 

Journal of Veterinary and Comparative Oncology 2012, 10, 3, Download attachmentse1-e29

 

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De bijdrage van de pathologie bij het klinisch opwerken van cutane mestceltumoren van de hond

E. van Garderen, J.H. Vos, N.M. Meertens, N.H. Peperkamp, K. Junker en J.P. de Vos.

 

Tijdschrift voor Diergeneeskunde 2012. 137: 30-37.

 

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Determination of platinum originating from carboplatin in human urine and canine excretion products by inductively coupled plasma mass spectrometry

Tine Janssens, Elke E.M. Brouwers, Johan P. de Vos, Jan H.M. Schellens, and Jos H. Beijnen.

 

Journal of Analytical Toxicology 2011. 35: 153-161.

 

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Canine tonsillar squamous cell carcinoma - a multi-centre retrospective review of 44 clinical cases.

A. Mas, L. Blackwood, P. Cripps, S. Murphy, J. de Vos, N. Dervisis, M. Martano and G. A. Polton.

 

Journal of Small Animal Practice 2011. 52: 359-364

 

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Determination of platinum originating from carboplatin in canine sebum and cerumen by inductively coupled plasma mass spectrometry

Tine Janssens, Elke E.M. Brouwers, Johan P. de Vos, Jan H.M. Schellens, and Jos H. Beijnen.

 

Journal of Pharmaceutical and Biomedical Analysis 2010 54: 395-400.

 

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Nowotwory komórek tucznych wystepujace u psów; ogólne spojrzenie i najnowsze istotne osiagniecia kliniczne - cz. I

Canine cutaneous mast cell tumours: an overview and new, clinical important, developments - part 1.

 

Estera Zawlocka-Hutny, Johan de Vos, Wojciech Hildebrand.

 

Weterynaria W Praktyce p.66-69 2010.

 

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Nowotwory komórek tucznych wystepujace u psów; ogólne spojrzenie i najnowsze istotne osiagniecia kliniczne - cz. II

Canine cutaneous mast cell tumours: an overview and new, clinical important, developments - part 2.

 

Estera Zawlocka-Hutny, Johan de Vos, Wojciech Hildebrand.

 

Weterynaria W Praktyce p.64-70 2010.

 

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Disseminated Penicillium radicum infection in a dog, clinically resembling multicentric malignant lymphoma

 

J.P. de Vos1, E. van Garderen2, H. Hensen3, I. Tange4, I. Curfs-Breuker5, B. Vandevelde1, J. F. Meis5.

 

Flemish Veterinary Journal 2009;78:183-188.

 

1De Ottenhorst, Clinic for Companion Animal Medicine and Veterinary Oncology Referral Centre, van Diemenstraat 83, 4535 AR Terneuzen, The Netherlands

2Laboratory for Pathology and Histology, Animal Health Service, Postbus 9, 7400 AA Deventer, The Netherlands

3Veterinary Clinic IJzendijke, Minnepoortstraat 14, 4515 BC, IJzendijke, The Netherlands

4Zorgsaam Foundation Zeeuws-Vlaanderen, Laboratory of Medical Microbiology, Wielingenlaan 2, 4535 PA Terneuzen, The Netherlands

5Department of Medical Microbiology and Infectious Diseases C70, Mycologie, Canisius-Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands

 

ABSTRACT

 

After detecting fungal organisms in smears of enlarged peripheral lymph nodes in a dog, determination was performed through culturing and genetic typing. The fungus was identified as Penicillium radicum by amplification of fungal DNA encoding of the ribosomal internal transcribed spacer region and comparison with DNA databases. In vitro susceptibility testing revealed multiresistance. In the literature, P. radicum is mentioned as a phosphate solubilizing agent used in agriculture for promoting plant growth. This is the first publication of a disseminated P. radicum infection in a dog. The generalized lymphadenopathy and hypercalcemia strongly resembled a multicentric lymphoma. Hypercalcemia in granulomatous diseases, including disseminated fungal infections, is caused by activated macrophages possessing 1α-hydroxylase, which is able to convert 25-hydroxyvitamin-D into calcitriol. Although disseminated fungal infections are extremely rare in The Netherlands and Belgium, they should be included in
the differential diagnosis of dogs with multicentric lymphadenopathy and hypercalcemia.
http://vdt.ugent.be/sites/default/files/art78306.pdf

 

 

67Gallium citrate scintigraphy to assess metatstatic spread in a dog with an oral melanoma


T. Liuti, J.P. de Vos, T. Bosman, C. van de Wiele, H. van Bree, K. Peremans.


Journal of Small Animal Practice 2009. 50: 31-34.


http://onlinelibrary.wiley.com/doi/10.1111/j.1748-5827.2008.00652.x/abstract

 
 

A transposition flap for reconstructing a large skin defect over the stifle and proximal tibia in a dog after removal of a hemangiopericytoma



J.P. de Vos, and J. Butinar.


Flemish Veterinary Journal 2008. 77: 106-112.
 
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Comparative aspects of pulmonary toxicity induced by cytotoxic agents with emphasis on lomustine, and a veterinary case report.



S.A.E. Van Meervenne, V. Bavegems, J.P. de Vos.


Flemish Veterinary Journal 2008. 77: 241-248.
 
 
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Therapy of brain tumors in dogs and cats.



S.A.E. Van Meervenne, J.P. de Vos, L.M.L. Van Ham.

Flemish Veterinary Journal 2007. 76: 165-176.
 

Piroxicam and carboplatin as a combination treatment of canine oral non-tonsillar squamous cell carcinoma



A pilot study and a literature review of a canine model of human head and neck squamous cell carcinoma.

J.P. de Vos, A.G. D. Burm, A.P. Focker, H. Boschloo, M. Karsijns and I. van der Waal.

Veterinary and Comparative Oncology 2005. 3: 16-24.
 
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Results from the treatment of advanced stage squamous cell carcinoma of the nasal planum in cats, using a combination of intralesional carboplatin and superficial radiotherapy:



A pilot study. J.P. de Vos, A.G.D. Burm and B.P. Focker.

Veterinary and Comparative Oncology 2004. 2: 75-81.
 
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Clustering in canine malignant lymphoma.

 
Teske E, de Vos JP, Egberink HF, Vos JH.

Veterinary Quarterly 1994. 16:134-136.
 
 

Listrophorus gibbus, a fur mite in domestic rabbits

 

J.P. de Vos, G.M. Dorrestein

ABSTRACT
A case of infection with the fur mite of domestic rabbits, Listrophorus gibbus, is reported. Possible methods of treatment of individual rabbits as well as of colonies of rabbits are reviewed. The presence of Listrophorus gibbus in conjunction with Cheyletiella parasitivorax is also discussed.

Tijdschrift voor diergeneeskunde 1978;103:695-698

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